TRASTUZUMAB DUOCARMAZINE FOR DUMMIES

The phosphorylated HER3 supplies docking web pages for p85 subunit of PI3K. The absolutely activated PI3K complex is generated by binding of p110 subunit of PI3K to p85 which is able to create PIP3 by using phosphorylating the PIP2. AKT binds to PIP3 and is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at equally threonine and serin pho